Coffee Bean Nuclei
Contents
Seen in –
- Granulosa cell tumors.
- Brenner tumor
Granulosa cell tumors
Tumors consists of – monotonous islands of granulosa cells with “coffee-bean” nuclei.
Same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by nests of transitional epithelial cells (urothelial) with longitudinal nuclear grooves (coffee bean nuclei) in abundant fibrous stroma
Brenner tumor
- Usually arises from squamous metaplasia of surface epithelium.
- Gross picture of Brenner is similar to that of fibroma.
- Histologically islands of transitional epithelium – Walthard nests.
- Compact fibrous stroma
- Cells look like “coffee bean” as the nuclei have longitudinal grooves.
Benign or Malignant
Majority are Benign, but some can be Malignant
- Benign Brenner tumor:
- Small usually < 2 cm
- circumscribed,
- fibrous tumor
- uniform cut surface
- Calcifications may be present
- Borderline and malignant Brenner tumor:
- Smooth surface,
- larger (usually > 10 cm)
- fleshy,
- polypoid masses projecting into cystic cavity(s)
