Cherry-red discoloration of the skin and blood
Cherry-red discoloration of the skin and blood
Cherry-red discoloration of the skin and blood found in which poisoning
[A] Digoxin
[B] Tetrodotoxin
[C] Botulinum
[D] Carbon monoxide
Cherry-red discoloration of the skin and blood
Cherry-red discoloration of the skin and blood
- Carbon monoxide poisoning
- CO toxicity is due to its effect on oxygen binding to the hemoglobin molecule.
- CO binds to hemoglobin forming carboxyhemoglobin (COHb) with a 220% greater affinity to hemoglobin than oxygen.
- Reduces in oxygen-carrying capacity of hemoglobin leads to cellular hypoxia.
- Leftward shift in the oxyhemoglobin dissociation curve – Carboxyhemoglobin (COHb) increases the affinity of unbound hemoglobin for O2 thus causing a leftward shift in the oxyhemoglobin dissociation curve.
- CO binds to the heme moiety of the cytochrome c oxidase in the electron transport chain and inhibits mitochondrial respiration.
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