Sacubitril
Contents
- 1 Sacubitril is a
- 2 Sacubitril is a pro-drug that, upon activation, acts as a
- 3 ALL of the following are TRUE for Neprilysin inhibition EXCEPT
- 4 What is the washout period when switching from an ACEi to sacubitril-valsartan
- 5 All of the following are TRUE about prescribing Sacubitril-valsartan EXCEPT
- 6 Natriuretic peptides are broken down by an enzyme called
- 7 ALL are TRUE regarding activated natriuretic peptide system EXCEPT
Sacubitril is a
[A] Antedrug
[B] Prodrug
[C] Metabolite
[D] Active drug
Sacubitril is a pro-drug that, upon activation, acts as a
[A] Angiotensin I receptor blocker
[B] Angiotensin II receptor blocker
[C] ACE inhibitor
[D] Neprilysin inhibitor
ALL of the following are TRUE for Neprilysin inhibition EXCEPT
[A] Increase bradykinin
[B] With an ACEi increased risk of angioedema
[C] Decrease angiotensin II levels
[D] Neprilysin inhibitor cannot be used alone
What is the washout period when switching from an ACEi to sacubitril-valsartan
[A] 12 hours
[B] 24 hours
[C] 36 hours
[D] 48 hours
All of the following are TRUE about prescribing Sacubitril-valsartan EXCEPT
[A] 36-hour washout period when switching from an ACEi
[B] Patients must be able to tolerate an ACEi or an ARB before being started on sacubitril-valsartan
[C] Not recommended for patients with hepatic impairment (Child-Pugh class C)
[D] Hypokalemia is a common side effect
Natriuretic peptides are broken down by an enzyme called
[A] Sacubitril
[B] Angiotensin II receptor blocker
[C] ACE
[D] Neprilysin
ALL are TRUE regarding activated natriuretic peptide system EXCEPT
[A] decreases blood pressure
[B] lowers sympathetic tone
[C] reduces aldosterone levels
[D] functions synergistically with RAAS
